Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.37 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SELP | P16109 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.31 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17764592 | 1.00 | STK17B (0.37) | STK17BSTK17ASYKSELPTYRO3 | |
| SCHEMBL17764663 | 0.82 | AXL (0.52) | TYRO3 | |
| SCHEMBL29437412 | 0.81 | STK17B (0.43) | STK17BSTK17ASYKKMT2AHCRTR1 | |
| SCHEMBL4549835 | 0.81 | STK17B (0.43) | STK17BSTK17ASYKKMT2AHCRTR1 | |
| SCHEMBL28454363 | 0.76 | MEN1 (0.32) | STK17BSTK17ASELPTYRO3MEN1 | |
| SCHEMBL17764557 | 0.73 | IRAK1 (0.40) | SELPTYRO3MEN1KMT2AADORA3 | |
| SCHEMBL22553562 | 0.73 | KMT2A (0.40) | SELPTYRO3MEN1KMT2A | |
| SCHEMBL22501580 | 0.73 | SELP (0.43) | SELPTYRO3MEN1KMT2AADORA3 | |
| SCHEMBL22501744 | 0.73 | KMT2A (0.40) | SELPTYRO3MEN1KMT2A | |
| SCHEMBL30990720 | 0.73 | KMT2A (0.40) | SELPTYRO3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221306-B1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |