Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | RECQL | P46063 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.64 |
| ▸ | BLM | P54132 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.64 |
| ▸ | THPO | P40225 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21557010 | 0.85 | KDM4E (0.66) | KDM4ETDP1LMNARECQLMAPT | |
| SCHEMBL18401481 | 0.85 | KDM4E (0.66) | KDM4ETDP1LMNARECQLMAPT | |
| SCHEMBL10305413 | 0.83 | KDM4E (0.64) | KDM4ETDP1LMNARECQLMAPT | |
| SCHEMBL20852494 | 0.80 | KDM4E (0.58) | KDM4ETDP1LMNARECQLMAPT | |
| Nordefrin SCHEMBL249722 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT | |
| Levonordefrin SCHEMBL6295856 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT | |
| Levonordefrin SCHEMBL29410156 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT | |
| Levonordefrin SCHEMBL14478222 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT | |
| Levonordefrin SCHEMBL119171 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT | |
| Nordefrin SCHEMBL29693041 | 0.78 | TDP1 (1.00) | KDM4ETDP1LMNARECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3567029-A1 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS | Lantheus Medical Imaging, Inc. (US) | 2019-11-13 | — | — | EP | disclosed |