Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 18/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21558019 | 0.94 | MAPK1 (0.59) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21557658 | 0.91 | MAPK1 (0.57) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21557655 | 0.91 | MAPK1 (0.61) | MAPK1 | |
| SCHEMBL21557993 | 0.90 | MAPK1 (0.72) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21557728 | 0.89 | MAPK1 (0.54) | MAPK1 | |
| SCHEMBL21557726 | 0.89 | MAPK1 (0.54) | MAPK1 | |
| SCHEMBL21557718 | 0.87 | MAPK1 (0.70) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21557683 | 0.87 | MAPK1 (0.53) | MAPK1BRD4 | |
| SCHEMBL21557729 | 0.87 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL25970979 | 0.86 | MAPK1 (0.59) | MAPK1PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |