Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 17/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22403218 | 0.93 | MAPK1 (0.46) | MAPK1CHEK1STAT6 | |
| SCHEMBL21557749 | 0.93 | MAPK1 (0.44) | MAPK1CHEK1STAT6 | |
| SCHEMBL30497101 | 0.93 | MAPK1 (0.46) | MAPK1P2RX7 | |
| SCHEMBL30497095 | 0.93 | MAPK1 (0.44) | MAPK1CHEK1STAT6 | |
| SCHEMBL21557684 | 0.93 | MAPK1 (0.46) | MAPK1P2RX7 | |
| SCHEMBL21557686 | 0.90 | MAPK1 (0.45) | MAPK1CHEK1STAT6P2RX7 | |
| SCHEMBL21557744 | 0.88 | MAPK1 (0.51) | MAPK1 | |
| SCHEMBL20503855 | 0.86 | MAPK1 (0.46) | MAPK1CHEK1STAT6 | |
| SCHEMBL20503951 | 0.86 | MAPK1 (0.49) | MAPK1CHEK1STAT6 | |
| SCHEMBL20503878 | 0.86 | MAPK1 (0.49) | MAPK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377491-B1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2019-11-13 | — | — | EP | disclosed |