Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.37 |
| ▸ | POLA1 | P09884 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 7/20 | 0.34 |
| ▸ | MMP8 | P22894 | 7/20 | 0.34 |
| ▸ | MMP9 | P14780 | 6/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29292388 | 0.96 | NR1H2 (0.40) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569815 | 0.93 | NR1H2 (0.38) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569828 | 0.88 | NR1H2 (0.35) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL29292402 | 0.88 | NR1H2 (0.43) | NR1H2NR1H3MMP3MMP8MMP9 | |
| SCHEMBL21569769 | 0.87 | NR1H2 (0.42) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL21569830 | 0.87 | NR1H2 (0.33) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569814 | 0.86 | NR1H2 (0.39) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569770 | 0.86 | NR1H2 (0.37) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569925 | 0.85 | NR1H2 (0.37) | NR1H2NR1H3POLA1RXRACCNE1 | |
| SCHEMBL21569768 | 0.85 | NR1H2 (0.40) | NR1H2NR1H3POLA1RXRACCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2019217591-A1 | ANTI-MSR1 ANTIBODIES AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2019-11-14 | — | — | WO | disclosed |