SCHEMBL21571310

SCHEMBL21571310

CC=CC(=O)N1CC(n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)C1

nearest known ligand 0.82

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FGFR2 P21802 20/20 0.82
▸ KDR P35968 5/20 0.82
▸ FGFR1 P11362 3/20 0.82
▸ FGFR4 P22455 3/20 0.82
▸ FGFR3 P22607 2/20 0.82
▸ BTK Q06187 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21571308 1.00 FGFR2 (0.82) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345761 0.93 FGFR2 (0.84) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345762 0.93 FGFR2 (0.84) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345429 0.91 FGFR2 (0.84) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345432 0.91 FGFR2 (0.84) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345392 0.90 FGFR2 (1.00) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345504 0.90 FGFR2 (0.83) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345507 0.90 FGFR2 (0.83) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15345524 0.89 FGFR2 (1.00) FGFR2KDRFGFR1FGFR4FGFR3
SCHEMBL15137950 0.89 FGFR2 (1.00) FGFR2KDRFGFR1FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11883404-B2 Preparation and composition for treatment of malignant tumors TAIHO PHARMACEUTICALS CO., LTD. (JP) 2024-01-30 — — US disclosed
US-20190350932-A1 PREPARATION AND COMPOSITION FOR TREATMENT OF MALIGNANT TUMORS TAIHO PHARMACEUTICAL CO., LTD. (JP) 2019-11-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11883404-B2 Preparation and composition for treatment of malignant tumors FGFR3, FGFR1, FGFR4 FGFR2 4/4885KDR 40/4885FGFR1 2/4885
US-20190350932-A1 PREPARATION AND COMPOSITION FOR TREATMENT OF MALIGNANT TUMORS FGFR3, FGFR1, FGFR4 FGFR2 4/4885KDR 40/4885FGFR1 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback