Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 11/20 | 1.00 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.83 |
| ▸ | FLT3 | P36888 | 3/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.83 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411294 | 1.00 | PLK4 (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL3415209 | 1.00 | PLK4 (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL9894728 | 1.00 | PLK4 (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL18559103 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL2576459 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL9946247 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL9947272 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL586573 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL19216506 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B | |
| SCHEMBL2544452 | 0.91 | AURKB (1.00) | PLK4AURKBFLT3CYP2C19GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47731-E1 | Kinase inhibitors and method of treating cancer with same | UNIV HEALTH NETWORK (CA) | 2019-11-19 | — | — | US | disclosed |