Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 12/20 | 0.80 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.80 |
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18760502 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18557135 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18557122 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18557123 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18557134 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18760506 | 1.00 | EPHX1 (0.80) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24308699 | 0.89 | EPHX1 (1.00) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15093798 | 0.89 | EPHX1 (1.00) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23960132 | 0.89 | EPHX1 (1.00) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24308701 | 0.89 | EPHX1 (1.00) | EPHX1EPHX2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3019483-B1 | THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-11-20 | — | — | EP | disclosed |