Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 20/20 | 0.84 |
| ▸ | SRC | P12931 | 2/20 | 0.82 |
| ▸ | KDR | P35968 | 2/20 | 0.82 |
| ▸ | STK25 | O00506 | 1/20 | 0.74 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.74 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.74 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.74 |
| ▸ | STK17B | O94768 | 1/20 | 0.74 |
| ▸ | STK10 | O94804 | 1/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.74 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.74 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.74 |
| ▸ | INSR | P06213 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18949476 | 0.93 | EGFR (0.79) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL24413897 | 0.90 | ERBB2 (1.00) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL14854735 | 0.90 | EGFR (0.72) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL14854738 | 0.90 | EGFR (0.72) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL14854737 | 0.90 | EGFR (0.72) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL14854736 | 0.90 | EGFR (0.72) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL18949475 | 0.89 | EGFR (0.86) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL18949452 | 0.88 | EGFR (0.81) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL31661419 | 0.86 | EGFR (0.85) | EGFRERBB2SRCKDRSTK25 | |
| SCHEMBL10014321 | 0.86 | ERBB2 (0.88) | EGFRERBB2SRCKDRSTK25 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222620-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2019-11-20 | — | — | EP | disclosed |