Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 15/20 | 0.58 |
| ▸ | STK25 | O00506 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | GAK | O14976 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | STK17B | O94768 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | FES | P07332 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | YES1 | P07947 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | HCK | P08631 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18949427 | 0.90 | EGFR (0.58) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14864938 | 0.89 | EGFR (0.59) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL18949434 | 0.89 | EGFR (0.55) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL18949482 | 0.89 | EGFR (0.60) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL19223117 | 0.88 | EGFR (0.47) | EGFRERBB2 | |
| SCHEMBL18949484 | 0.85 | EGFR (0.56) | EGFRERBB2 | |
| SCHEMBL18933434 | 0.84 | EGFR (0.56) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14864928 | 0.84 | EGFR (0.74) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14864924 | 0.84 | EGFR (0.55) | EGFRERBB2STK25CITCHEK1 | |
| SCHEMBL14864936 | 0.81 | EGFR (0.61) | EGFRERBB2STK25CITCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3222620-B1 | CYANOQUINOLINE DERIVATIVES | TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO LTD (CN) | 2019-11-20 | — | — | EP | disclosed |