Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 16/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FSHR | P23945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18191572 | 0.92 | NR1H4 (0.67) | NR1H4MEN1KMT2AKDM4ETSHR | |
| SCHEMBL18191598 | 0.91 | NR1H4 (0.65) | NR1H4MEN1KMT2AKDM4ETSHR | |
| SCHEMBL18191658 | 0.87 | NR1H4 (0.61) | NR1H4MEN1KMT2A | |
| SCHEMBL18191656 | 0.87 | NR1H4 (0.61) | NR1H4POLB | |
| SCHEMBL18191605 | 0.86 | NR1H4 (0.64) | NR1H4POLBMAPT | |
| SCHEMBL18191674 | 0.86 | NR1H4 (0.64) | NR1H4 | |
| SCHEMBL18191662 | 0.85 | NR1H4 (0.67) | NR1H4POLBMAPT | |
| SCHEMBL18191645 | 0.85 | NR1H4 (0.67) | NR1H4POLBMAPT | |
| SCHEMBL18198056 | 0.85 | NR1H4 (0.69) | NR1H4POLBMAPT | |
| SCHEMBL18191636 | 0.85 | NR1H4 (0.66) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-107531721-B | Fused tricyclic pyrazole derivatives for modulating farnesoid X receptors | 诺华股份有限公司 | 2020-07-17 | — | — | CN | disclosed |
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |