Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 17/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18191614 | 0.89 | NR1H4 (0.72) | NR1H4POLBMAPT | |
| SCHEMBL18191578 | 0.87 | NR1H4 (0.69) | NR1H4POLBMAPT | |
| SCHEMBL18198075 | 0.87 | NR1H4 (0.67) | NR1H4MAPT | |
| SCHEMBL16702203 | 0.86 | NR1H4 (0.67) | NR1H4POLBMAPT | |
| SCHEMBL18191629 | 0.86 | NR1H4 (0.67) | NR1H4POLBMAPT | |
| SCHEMBL18191628 | 0.83 | NR1H4 (0.60) | NR1H4POLBMAPT | |
| SCHEMBL16702092 | 0.83 | NR1H4 (0.64) | NR1H4POLBMAPT | |
| SCHEMBL16703004 | 0.83 | NR1H4 (0.72) | NR1H4POLBMAPT | |
| SCHEMBL21574217 | 0.83 | NR1H4 (0.63) | NR1H4POLBMAPT | |
| SCHEMBL16702933 | 0.83 | NR1H4 (0.65) | NR1H4POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |