Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 19/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18191650 | 0.91 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191604 | 0.91 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191646 | 0.91 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191601 | 0.91 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191583 | 0.89 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191586 | 0.89 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL18191623 | 0.88 | NR1H4 (1.00) | NR1H4MAPT | |
| SCHEMBL21574274 | 0.86 | NR1H4 (0.65) | NR1H4LMNATP53MAPT | |
| SCHEMBL28897395 | 0.83 | NR1H4 (0.86) | NR1H4MAPT | |
| SCHEMBL18191597 | 0.83 | NR1H4 (1.00) | NR1H4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288948-B1 | FUSED TRICYCLIC PYRAZOLE DERIVATIVES USEFUL FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2019-11-20 | — | — | EP | disclosed |