Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.63 |
| ▸ | PRKCB | P05771 | 6/20 | 0.63 |
| ▸ | CDK4 | P11802 | 6/20 | 0.63 |
| ▸ | CDK2 | P24941 | 5/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.63 |
| ▸ | TGFBR2 | P37173 | 3/20 | 0.62 |
| ▸ | GSK3A | P49840 | 14/20 | 0.61 |
| ▸ | CAMK2G | Q13555 | 3/20 | 0.60 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.60 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.60 |
| ▸ | PRKCG | P05129 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | CDK1 | P06493 | 2/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.60 |
| ▸ | CLK2 | P49760 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21577709 | 0.92 | GSK3B (0.63) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL20439158 | 0.87 | GSK3B (0.78) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577590 | 0.86 | GSK3B (0.66) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577592 | 0.81 | GSK3B (0.79) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577660 | 0.79 | GSK3B (0.80) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577659 | 0.79 | GSK3B (0.80) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL29534407 | 0.79 | GSK3B (0.80) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577596 | 0.78 | GSK3B (0.71) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL21577573 | 0.78 | GSK3B (0.71) | GSK3BPRKCBCDK4CDK2PDK1 | |
| SCHEMBL29534131 | 0.77 | GSK3B (0.66) | GSK3BPRKCBCDK4CDK2PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2019-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190352313-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | GSK3B 3641/4885PRKCB 1923/4885CDK4 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.