Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15561338 | 0.84 | MEN1 (0.39) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL24928346 | 0.84 | MEN1 (0.46) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL19183181 | 0.81 | MEN1 (0.49) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL15561339 | 0.81 | CA12 (0.41) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL15561375 | 0.80 | MEN1 (0.42) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL28271381 | 0.80 | TDP1 (0.54) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL28350247 | 0.80 | EPHX2 (0.41) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL17871111 | 0.79 | TSHR (0.46) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL15561329 | 0.78 | CA12 (0.44) | MEN1KMT2AGAAALDH1A1TSHR | |
| SCHEMBL15561411 | 0.78 | CA12 (0.44) | MEN1KMT2AGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3575294-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Les Laboratoires Servier (FR) | 2019-12-04 | — | — | EP | disclosed |