Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 19/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158684 | 0.79 | SMO (0.78) | SMOKCNH2EPHX1EPHX2CACNA1C | |
| SCHEMBL30506309 | 0.78 | EPHX2 (1.00) | SMOKCNH2EPHX1EPHX2CACNA1C | |
| SCHEMBL20116328 | 0.78 | EPHX2 (1.00) | SMOKCNH2EPHX1EPHX2CACNA1C | |
| Trifluoroacetic Acid SCHEMBL2158258 | 0.78 | SMO (0.88) | SMOKCNH2EPHX1EPHX2CACNA1C | |
| Trifluoroacetic Acid SCHEMBL2158204 | 0.76 | SMO (0.90) | SMO | |
| Trifluoroacetic Acid SCHEMBL2159043 | 0.76 | SMO (0.63) | SMOKCNH2EPHX2CACNA1C | |
| Trifluoroacetic Acid SCHEMBL2158835 | 0.75 | SMO (0.89) | SMOKCNH2EPHX1EPHX2CACNA1C | |
| SCHEMBL2157965 | 0.74 | SMO (1.00) | SMO | |
| SCHEMBL22358393 | 0.73 | SMO (0.77) | SMOKCNH2 | |
| SCHEMBL20116326 | 0.73 | SMO (0.69) | SMOKCNH2EPHX1EPHX2CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI (IT) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183974-A1 | 1,2,4-OXADIAZOLE SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES AS SMO ANTAGONISTS | SHH, SMO, GLI1 | SMO 2/4885KCNH2 3528/4885EPHX1 2252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.