Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MITF | O75030 | 1/20 | 0.64 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.57 |
| ▸ | MYC | P01106 | 1/20 | 0.55 |
| ▸ | MAX | P61244 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19999093 | 1.00 | MAPT (0.70) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL18103040 | 0.90 | MEN1 (0.67) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL20005767 | 0.88 | MAPT (0.56) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL14407429 | 0.78 | MAPT (0.70) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL12008472 | 0.78 | MAPT (1.00) | MAPTALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL4132883 | 0.77 | MAPT (0.64) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL4132886 | 0.77 | MAPT (0.64) | MAPTALDH1A1MAPK1KDM4ELMNA | |
| SCHEMBL6886677 | 0.76 | AKR1B1 (0.83) | MAPTALDH1A1MEN1KMT2ANCOA3 | |
| SCHEMBL6886682 | 0.76 | AKR1B1 (0.83) | MAPTALDH1A1MEN1KMT2ANCOA3 | |
| SCHEMBL12008473 | 0.76 | MAPT (0.88) | MAPTALDH1A1KDM4ELMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | UNIVERSITY OF MIAMI (US) | 2019-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10501413-B2 | Inhibitors of the Notch transcriptional activation complex and methods for use of the same | NOTCH1, CBFB, HES1 | MAPT 3938/4885ALDH1A1 2177/4885MAPK1 2158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.