Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 13/20 | 0.53 |
| ▸ | TLR9 | Q9NR96 | 16/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 16/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24404813 | 0.92 | TLR8 (0.58) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL16634341 | 0.92 | TLR8 (0.58) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL16633372 | 0.92 | TLR8 (0.58) | TLR8TLR9TLR7ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL16632234 | 0.91 | TLR8 (0.57) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL23794862 | 0.86 | TLR8 (0.47) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL16633643 | 0.85 | TLR8 (0.52) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL24404814 | 0.85 | TLR8 (0.52) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL16634023 | 0.85 | TLR8 (0.52) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL19829021 | 0.85 | TLR8 (0.52) | TLR8TLR9TLR7ALDH1A1GAA | |
| SCHEMBL25701692 | 0.85 | TLR8 (0.52) | TLR8TLR9TLR7ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3877388-A1 | 5-[6-[[3-(4,5,6,7-TETRAHYDROPYRAZOLO[4,3-C]PYRIDIN-1-YL)AZETIDIN-1-YL]METHYL]MORPHOLIN-4-YL]QUINOLINE-8-CARBONITRILE DERIVATIVES AND SIMILAR COMPOUNDS AS TLR7-9 ANTAGONISTS FOR TREATING SYSTEMIC LUPUS ERYTHEMATOSUS | F. Hoffmann-La Roche AG (CH) | 2021-09-15 | — | — | EP | disclosed |
| EP-3856737-A1 | HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-08-04 | — | — | EP | disclosed |
| EP-3807271-A1 | PYRIDINYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2021-04-21 | — | — | EP | disclosed |
| WO-2020064792-A1 | HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2020-04-02 | — | — | WO | disclosed |
| WO-2019238629-A1 | PYRIDINYL HETEROCYCLYL COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2019-12-19 | — | — | WO | disclosed |