Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14298953 | 1.00 | CHRM2 (0.35) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL15807506 | 0.91 | CHRM2 (0.34) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL2147530 | 0.91 | CHRM2 (0.34) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL12461044 | 0.91 | CHRM2 (0.34) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL12460799 | 0.91 | CHRM2 (0.34) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL2147497 | 0.91 | CHRM2 (0.34) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL2148336 | 0.89 | CHEK1 (0.32) | KDM4EALDH1A1CHEK1CCNA2CDK2 | |
| SCHEMBL2148341 | 0.89 | CHEK1 (0.32) | KDM4EALDH1A1CHEK1CCNA2CDK2 | |
| SCHEMBL28913 | 0.89 | EIF2AK4 (0.33) | CHRM2CHRM1CHRM3EIF2AK4SUV39H2 | |
| SCHEMBL2147240 | 0.88 | EIF2AK4 (0.37) | CHRM2CHRM1CHRM3EIF2AK4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |