Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.66 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.50 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.45 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.45 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.45 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL214967 | 0.99 | KDM1A (0.64) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL20567645 | 0.88 | KDM1A (0.60) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL213097 | 0.84 | KDM1A (0.56) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL3794778 | 0.83 | KDM1A (0.54) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL6495125 | 0.82 | KDM1A (0.54) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL3992131 | 0.82 | KDM1A (0.44) | KDM1AGPR119 | |
| SCHEMBL19402410 | 0.81 | KDM1A (0.58) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL19839235 | 0.81 | PDE4B (0.64) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL21765007 | 0.81 | KDM1A (0.57) | KDM1AGPR119PDE4BPDE4DPDE4A | |
| SCHEMBL74564 | 0.81 | KDM1A (0.57) | KDM1AGPR119PDE4BPDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100136136-A1 | JAK-2 Modulators and Methods of Use | JAK2, JAK1, JAK3 | KDM1A 963/4885GPR119 2016/4885PDE4B 1998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.