SCHEMBL21592222

SCHEMBL21592222

C[C@H](Cn1cnc2c(N)ncnc21)OCPNCCOCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 10/20 0.48
ADORA2A P29274 3/20 0.47
PI4KA P42356 1/20 0.47
PI4K2B Q8TCG2 1/20 0.47
PI4K2A Q9BTU6 1/20 0.47
PI4KB Q9UBF8 1/20 0.47
ADORA1 P30542 1/20 0.44
CYP2D6 P10635 10/20 0.43
ALDH1A1 P00352 1/20 0.42
LMNA P02545 1/20 0.41
HPGD P15428 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
FAP Q12884 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23516234 0.88 CYP3A4 (0.53) CYP3A4ADORA2API4KAPI4K2BPI4K2A
SCHEMBL21592220 0.88 ADORA2A (0.45) CYP3A4ADORA2API4KAPI4K2BPI4K2A
SCHEMBL27886800 0.82 CYP3A4 (0.61) CYP3A4ADORA2API4KAPI4K2BPI4K2A
SCHEMBL16397567 0.82 CYP3A4 (0.61) CYP3A4ADORA2API4KAPI4K2BPI4K2A
SCHEMBL21592219 0.79 CYP3A4 (0.54) CYP3A4CYP2D6FAP
SCHEMBL21592218 0.79 CYP3A4 (0.54) CYP3A4CYP2D6FAP
SCHEMBL20324292 0.79 CYP3A4 (0.54) CYP3A4CYP2D6FAP
SCHEMBL20324259 0.76 CYP3A4 (0.53) CYP3A4CYP2D6FAP
SCHEMBL20324845 0.76 CYP3A4 (0.51) CYP3A4CYP2D6FAP
SCHEMBL21592221 0.76 CYP3A4 (0.56) CYP3A4ADORA2API4KAPI4K2BPI4K2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3808752-A1 PHOSPHONAMIDE ESTER COMPOUND, SALT THEREOF, RELATED CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (CN) 2021-04-21 EP disclosed
WO-2019237957-A1 PHOSPHONAMIDE ESTER COMPOUND, SALT THEREOF, RELATED CRYSTAL FORM THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 四川科伦博泰生物医药股份有限公司 2019-12-19 WO disclosed