Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.71 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | IL2 | P60568 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592435 | 0.90 | MAP4K1 (0.77) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592700 | 0.86 | MAP4K1 (0.73) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592620 | 0.86 | MAP4K1 (0.64) | MAP4K1CHEK1 | |
| SCHEMBL21592526 | 0.86 | MAP4K1 (0.66) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592624 | 0.85 | MAP4K1 (0.83) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL28509578 | 0.85 | MAP4K1 (0.70) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592553 | 0.85 | MAP4K1 (0.65) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL28514863 | 0.85 | MAP4K1 (0.74) | MAP4K1CHEK1CLK1DYRK1AMAPK1 | |
| SCHEMBL21592760 | 0.84 | MAP4K1 (0.59) | MAP4K1CLK1DYRK1AIL2 | |
| SCHEMBL21592494 | 0.84 | MAP4K1 (0.81) | MAP4K1CHEK1CLK1DYRK1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |