Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.51 |
| ▸ | IL2 | P60568 | 3/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592835 | 0.91 | MAP4K1 (0.60) | MAP4K1IL2TNIKMAP3K11FLT3 | |
| SCHEMBL28504698 | 0.83 | TNIK (0.55) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL21592853 | 0.82 | MAP4K1 (0.64) | MAP4K1IL2MAP3K11DYRK1A | |
| SCHEMBL21592978 | 0.78 | MAP4K1 (0.59) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL21592578 | 0.77 | MAP4K1 (0.50) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL28502534 | 0.76 | MAP4K1 (0.46) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL21593019 | 0.76 | MAP4K1 (0.49) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL21592927 | 0.76 | MAP3K11 (0.57) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL21592423 | 0.75 | MAP4K1 (0.72) | MAP4K1IL2TNIKMAP3K11DYRK1A | |
| SCHEMBL28605040 | 0.74 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |