Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504546 | 0.85 | MAP4K1 (0.70) | MAP4K1MAPK1IL2CHEK1RPS6KA3 | |
| SCHEMBL21592729 | 0.85 | MAP4K1 (0.61) | MAP4K1MAPK1CLK1DYRK1ACHEK1 | |
| SCHEMBL28509493 | 0.85 | MAP4K1 (0.69) | MAP4K1MAPK1IL2CHEK1RPS6KA3 | |
| SCHEMBL21592642 | 0.84 | MAP4K1 (0.64) | MAP4K1MAPK1CLK1DYRK1AIL2 | |
| SCHEMBL21593065 | 0.84 | MAP4K1 (0.68) | MAP4K1MAPK1CLK1DYRK1AIL2 | |
| SCHEMBL21592474 | 0.84 | MAP4K1 (0.77) | MAP4K1MAPK1IL2RPS6KA3 | |
| SCHEMBL21592496 | 0.84 | MAP4K1 (0.68) | MAP4K1MAPK1IL2RPS6KA3 | |
| SCHEMBL21592718 | 0.83 | MAP4K1 (0.67) | MAP4K1MAPK1CLK1DYRK1AIL2 | |
| SCHEMBL21592460 | 0.83 | MAP4K1 (0.67) | MAP4K1MAPK1IL2CHEK1RPS6KA3 | |
| SCHEMBL21592513 | 0.82 | MAPK1 (0.69) | MAP4K1MAPK1IL2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |