Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 10/20 | 0.55 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.53 |
| ▸ | IL2 | P60568 | 3/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592637 | 0.90 | MAP4K1 (0.59) | MAP4K1TNIKIL2MAP3K11ABL1 | |
| SCHEMBL21592804 | 0.88 | MAP4K1 (0.55) | MAP4K1TNIKIL2MAP3K11ABL1 | |
| SCHEMBL21592885 | 0.88 | MAP4K1 (0.57) | MAP4K1TNIKIL2MAP3K11CYP3A4 | |
| SCHEMBL21592882 | 0.87 | MAP4K1 (0.62) | MAP4K1TNIKIL2MAP3K11IGF1R | |
| SCHEMBL21592978 | 0.87 | MAP4K1 (0.59) | MAP4K1TNIKIL2MAP3K11CYP3A4 | |
| SCHEMBL21592989 | 0.86 | KIT (0.53) | MAP4K1TNIKIL2MAP3K11IGF1R | |
| SCHEMBL21592894 | 0.86 | MAP4K1 (0.60) | MAP4K1TNIKIL2MAP3K11CYP3A4 | |
| SCHEMBL21592647 | 0.86 | MAP4K1 (0.62) | MAP4K1TNIKIL2MAP3K11CYP3A4 | |
| SCHEMBL21592563 | 0.86 | MAP4K1 (0.60) | MAP4K1TNIKIL2MAP3K11ABL1 | |
| Ammonia Solution, Strong SCHEMBL28502436 | 0.85 | MAP3K11 (0.46) | MAP4K1TNIKIL2MAP3K11SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |