Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 11/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.46 |
| ▸ | IL2 | P60568 | 3/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592942 | 0.89 | MAP4K1 (0.54) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592516 | 0.86 | MAP4K1 (0.59) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592605 | 0.85 | MAP4K1 (0.58) | MAP3K11TNIKMAP4K1IL2SGK1 | |
| SCHEMBL21592695 | 0.84 | MAP4K1 (0.56) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL28905284 | 0.82 | SGK1 (0.57) | MAP3K11TNIKMAP4K1IL2SGK1 | |
| SCHEMBL21592671 | 0.82 | MAP4K1 (0.55) | MAP3K11TNIKMAP4K1IL2SGK1 | |
| SCHEMBL21592814 | 0.79 | MAP4K1 (0.65) | MAP3K11TNIKMAP4K1 | |
| SCHEMBL21592757 | 0.79 | MAP4K1 (0.54) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592507 | 0.78 | MAP4K1 (0.61) | MAP3K11TNIKMAP4K1IL2 | |
| SCHEMBL21592455 | 0.78 | TNIK (0.57) | MAP3K11TNIKMAP4K1IL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |