Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 13/20 | 0.85 |
| ▸ | MAP3K11 | Q16584 | 8/20 | 0.80 |
| ▸ | IKBKB | O14920 | 2/20 | 0.66 |
| ▸ | CHUK | O15111 | 2/20 | 0.66 |
| ▸ | ABL1 | P00519 | 2/20 | 0.66 |
| ▸ | INSR | P06213 | 2/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.66 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.65 |
| ▸ | SGK1 | O00141 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.64 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | MET | P08581 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592535 | 0.92 | TNIK (0.73) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL22971589 | 0.90 | MAP3K11 (0.84) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL723895 | 0.89 | MAP3K11 (1.00) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL722116 | 0.89 | MAP3K11 (1.00) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL21592611 | 0.89 | TNIK (0.68) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL721214 | 0.88 | TNIK (0.85) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL21592655 | 0.86 | TNIK (0.65) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL21592464 | 0.86 | TNIK (0.64) | TNIKMAP3K11MAP4K1SGK1CYP3A4 | |
| SCHEMBL12065847 | 0.86 | TNIK (0.83) | TNIKMAP3K11IKBKBCHUKABL1 | |
| SCHEMBL22971590 | 0.85 | TNIK (1.00) | TNIKMAP3K11IKBKBCHUKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |