Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.58 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.56 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.51 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.46 |
| ▸ | SGK1 | O00141 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592566 | 0.91 | MAP4K1 (0.65) | MAP4K1TNIKMAP3K11CAMKK2SGK1 | |
| SCHEMBL21592546 | 0.89 | MAP4K1 (0.68) | MAP4K1TNIKMAP3K11MAP3K9CAMKK2 | |
| SCHEMBL21592867 | 0.86 | MAP4K1 (0.78) | MAP4K1TNIKMAP3K11MAP3K9CAMKK2 | |
| SCHEMBL21592924 | 0.86 | MAP4K1 (0.60) | MAP4K1TNIKMAP3K11CAMKK2SGK1 | |
| SCHEMBL21592926 | 0.85 | MAP4K1 (0.78) | MAP4K1TNIKMAP3K11CAMKK2SGK1 | |
| SCHEMBL21592914 | 0.85 | MAP4K1 (0.65) | MAP4K1TNIKMAP3K11MAP3K9CAMKK2 | |
| SCHEMBL21592972 | 0.85 | MAP4K1 (0.59) | MAP4K1TNIKMAP3K11MAP3K9CAMKK2 | |
| SCHEMBL21592743 | 0.85 | MAP4K1 (0.56) | MAP4K1TNIKMAP3K11AXL | |
| SCHEMBL21592569 | 0.85 | MAP4K1 (0.62) | MAP4K1TNIKMAP3K11CAMKK2SGK1 | |
| SCHEMBL21592852 | 0.83 | MAP4K1 (0.60) | MAP4K1TNIKMAP3K11CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |