Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.61 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922399 | 0.95 | MAP4K1 (0.57) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592732 | 0.91 | MAP4K1 (0.64) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592724 | 0.89 | MAP4K1 (0.67) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL21592719 | 0.89 | MAP4K1 (0.63) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL22922593 | 0.88 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL21592649 | 0.88 | MAP4K1 (0.65) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL22858774 | 0.87 | MAP4K1 (0.72) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL29608985 | 0.87 | MAP4K1 (0.72) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL22922401 | 0.86 | MAP4K1 (0.63) | MAP4K1MAP3K11JAK2JAK1TYK2 | |
| SCHEMBL22922398 | 0.86 | MAP4K1 (0.63) | MAP4K1MAP3K11JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |