Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 5/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 5/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592990 | 0.89 | NTRK1 (0.54) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592929 | 0.86 | MAP3K11 (0.52) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL28501993 | 0.84 | MAP3K11 (0.49) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592788 | 0.83 | MAP4K1 (0.58) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592866 | 0.81 | MAP4K1 (0.52) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592568 | 0.81 | MAP4K1 (0.56) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592861 | 0.80 | MAP3K11 (0.52) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL24723493 | 0.80 | MAP4K1 (0.63) | MAP3K11IGF1RMAP4K1TNIKIL2 | |
| SCHEMBL21592787 | 0.80 | IGF1R (0.51) | MAP3K11IGF1RMAP4K1TNIKNTRK1 | |
| SCHEMBL21592901 | 0.80 | MAP4K1 (0.75) | MAP3K11IGF1RMAP4K1TNIKNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |