Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.47 |
| ▸ | CDC42BPB | Q9Y5S2 | 8/20 | 0.47 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | SGK1 | O00141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593039 | 1.00 | MAP4K1 (0.52) | MAP4K1ROCK2ROCK1CDC42BPBTNIK | |
| SCHEMBL21593025 | 1.00 | MAP4K1 (0.52) | MAP4K1ROCK2ROCK1CDC42BPBTNIK | |
| SCHEMBL21592998 | 0.95 | MAP4K1 (0.53) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21592820 | 0.95 | MAP4K1 (0.53) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21593000 | 0.95 | MAP4K1 (0.53) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21592618 | 0.90 | MAP4K1 (0.55) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21592825 | 0.89 | MAP4K1 (0.60) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21593042 | 0.88 | MAP4K1 (0.59) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21592963 | 0.86 | MAP4K1 (0.57) | MAP4K1TNIKPIK3CGCAMKK2ABL1 | |
| SCHEMBL21592936 | 0.85 | MAP4K1 (0.61) | MAP4K1TNIKPIK3CGCAMKK2MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |