Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIK2 | Q9H0K1 | 16/20 | 0.50 |
| ▸ | SIK3 | Q9Y2K2 | 9/20 | 0.42 |
| ▸ | SIK1 | P57059 | 8/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593330 | 0.77 | SIK2 (0.58) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL24169269 | 0.77 | SIK2 (0.58) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL22747321 | 0.76 | SIK2 (0.55) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL21593351 | 0.76 | SIK2 (0.47) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL24169470 | 0.75 | SIK2 (0.54) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL22747322 | 0.72 | SIK2 (0.51) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL30130914 | 0.72 | SIK2 (0.58) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL21593406 | 0.71 | SIK2 (0.49) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL30131022 | 0.70 | SIK2 (0.50) | SIK2SIK3SIK1RIPK2ABL1 | |
| SCHEMBL32691316 | 0.68 | SIK2 (0.56) | SIK2SIK3SIK1RIPK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238424-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES | GALAPAGOS NV (BE) | 2019-12-19 | — | — | WO | disclosed |