Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19654457 | 0.88 | KMT2A (0.55) | KMT2AAXLSYKADORA3ADORA2A | |
| SCHEMBL1783010 | 0.84 | KMT2A (0.65) | KMT2AAXLSYKADORA3ADORA2A | |
| SCHEMBL12069200 | 0.83 | KMT2A (0.68) | KMT2AAXLADORA3ADORA2AADORA1 | |
| SCHEMBL13649056 | 0.82 | KMT2A (0.48) | KMT2AAXLBTKPIM1ADORA3 | |
| SCHEMBL20330316 | 0.81 | KMT2A (0.47) | KMT2AAXLBTKSYKPIM1 | |
| SCHEMBL21593675 | 0.81 | KMT2A (0.49) | KMT2AAXLBTKADORA3ADORA2A | |
| SCHEMBL12067756 | 0.81 | MAPK1 (0.50) | KMT2AAXLBTKADORA3PIK3CA | |
| SCHEMBL21593674 | 0.81 | KMT2A (0.49) | KMT2AAXLSYKADORA3ADORA2A | |
| SCHEMBL1783841 | 0.81 | KMT2A (0.49) | KMT2AAXLCLK4 | |
| SCHEMBL21593667 | 0.80 | KMT2A (0.46) | KMT2AAXLBTKSYKPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238929-A1 | PURINONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2019-12-19 | — | — | WO | disclosed |