Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 20/20 | 0.81 |
| ▸ | DDX5 | P17844 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24642764 | 0.92 | TOP1 (0.83) | TOP1DDX5 | |
| SCHEMBL29065855 | 0.90 | TOP1 (0.82) | TOP1DDX5 | |
| SCHEMBL21450571 | 0.90 | TOP1 (0.82) | TOP1DDX5 | |
| SCHEMBL21450329 | 0.90 | TOP1 (0.87) | TOP1 | |
| SCHEMBL15711952 | 0.90 | TOP1 (1.00) | TOP1 | |
| SCHEMBL21450568 | 0.89 | TOP1 (0.80) | TOP1DDX5 | |
| SCHEMBL21450459 | 0.89 | TOP1 (0.89) | TOP1 | |
| SCHEMBL9563446 | 0.89 | TOP1 (0.89) | TOP1 | |
| SCHEMBL23235265 | 0.88 | TOP1 (1.00) | TOP1 | |
| SCHEMBL21450485 | 0.88 | TOP1 (0.87) | TOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110590796-B | Camptothecin derivative and preparation method and application thereof | 青岛海洋生物医药研究院股份有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-110590796-A | Camptothecin derivative and preparation method and application thereof | 青岛海洋生物医药研究院股份有限公司 | 2019-12-20 | — | — | CN | disclosed |
| WO-2019238046-A1 | CAMPTOTHECIN DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 青岛海洋生物医药研究院股份有限公司 | 2019-12-19 | — | — | WO | disclosed |