Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | GRM5 | P41594 | 2/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30763254 | 1.00 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL28438775 | 0.84 | GRM5 (0.64) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL5201549 | 0.83 | GRM5 (0.62) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL21595574 | 0.82 | KMT2A (0.50) | SMN1; SMN2NPC1GRM5RAB9AKMT2A | |
| SCHEMBL30763177 | 0.82 | KMT2A (0.50) | SMN1; SMN2NPC1GRM5RAB9AKMT2A | |
| SCHEMBL28492426 | 0.82 | GRM5 (0.60) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL12090707 | 0.81 | GRM5 (0.59) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL29643946 | 0.81 | GRM5 (0.59) | SMN1; SMN2NPC1GRM5P2RX7RAB9A | |
| SCHEMBL29930319 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1GRM5RAB9AKMT2A | |
| SCHEMBL5285570 | 0.78 | HDAC3 (0.71) | SMN1; SMN2NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810597-B1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | UNIV OSLO HF (NO) | 2025-11-26 | — | — | EP | disclosed |
| US-11926614-B2 | 1,2,4-triazole derivatives as tankyrase inhibitors | OSLO UNIVERSITETSSYKEHUS HF (NO) | 2024-03-12 | — | — | US | disclosed |
| EP-3810597-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | Oslo Universitetssykehus HF (NO) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243822-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS TANKYRASE INHIBITORS | OSLO UNIVERSITETSSYKEHUS HF (NO) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11926614-B2 | 1,2,4-triazole derivatives as tankyrase inhibitors | GBA3, CBR3, TECR | SMN1; SMN2 4006/4885NPC1 1998/4885GRM5 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.