Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 3/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218653 | 0.91 | S1PR4 (0.47) | S1PR4MRGPRX4PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL21601495 | 0.83 | S1PR4 (0.49) | S1PR4MRGPRX4PPARGPPARAFFAR1 | |
| SCHEMBL30025714 | 0.81 | S1PR4 (0.48) | S1PR4MRGPRX4PPARGPPARAFFAR1 | |
| SCHEMBL5317553 | 0.81 | S1PR4 (0.48) | S1PR4MRGPRX4PPARGPPARAFFAR1 | |
| SCHEMBL19555362 | 0.81 | S1PR4 (0.48) | S1PR4MRGPRX4PPARGPPARAFFAR1 | |
| SCHEMBL3864712 | 0.81 | ALOX5AP (0.44) | PTGS2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4334537 | 0.81 | S1PR4 (0.61) | S1PR4MRGPRX4TP53MAPK1L3MBTL1 | |
| SCHEMBL5318910 | 0.80 | S1PR4 (0.47) | S1PR4MRGPRX4LMNAPPARGPPARA | |
| SCHEMBL2252284 | 0.79 | MRGPRX4 (0.48) | S1PR4MRGPRX4PPARGPPARAFFAR1 | |
| SCHEMBL12505493 | 0.78 | MAPT (0.49) | S1PR4ALDH1A1LMNATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019244066-A2 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019244066-A2 | PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | VIIV Healthcare UK (No.5) Limited (GB) | 2019-12-26 | — | — | WO | disclosed |