Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 9/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600886 | 0.91 | FGFR4 (0.53) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL21600947 | 0.90 | FGFR4 (0.48) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL21601052 | 0.89 | FGFR4 (0.54) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL23581181 | 0.89 | FGFR4 (0.52) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL21600893 | 0.85 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL21596334 | 0.85 | FGFR1 (0.50) | FGFR1FGFR4FGFR2FGFR3JAK3 | |
| SCHEMBL21600912 | 0.84 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3MAPK10 | |
| SCHEMBL21596399 | 0.84 | FGFR4 (0.51) | FGFR1FGFR4FGFR2FGFR3JAK3 | |
| SCHEMBL21600961 | 0.84 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3JAK3 | |
| SCHEMBL21600890 | 0.84 | FGFR1 (0.49) | FGFR1FGFR4FGFR2FGFR3JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |