Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.40 |
| ▸ | PTPRC | P08575 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.39 |
| ▸ | PTPRB | P23467 | 2/20 | 0.39 |
| ▸ | PTPRE | P23469 | 2/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30148439 | 0.84 | MAPT (0.52) | HPGDALDH1A1HSD17B10TSHRMAPT | |
| SCHEMBL21597690 | 0.84 | CNR2 (0.43) | FLT3ALDH1A1TSHRMAPTLMNA | |
| SCHEMBL21597159 | 0.74 | FLT3 (0.67) | FLT3HPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL30148402 | 0.74 | FLT3 (0.67) | FLT3HPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL30148408 | 0.74 | FLT3 (0.67) | FLT3HPGDALDH1A1HSD17B10TSHR | |
| SCHEMBL28610570 | 0.73 | KDM4E (0.52) | HPGDALDH1A1HSD17B10TSHRMAPT | |
| SCHEMBL21603914 | 0.71 | KDM4E (0.70) | FLT3HPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL28618673 | 0.71 | KDM4E (0.70) | FLT3HPGDALDH1A1HSD17B10MAPT | |
| SCHEMBL21597466 | 0.69 | KDM4E (0.53) | PTPN1FLT3HSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL28611808 | 0.68 | KMT2A (0.51) | HPGDALDH1A1HSD17B10TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |