Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CHD1L | Q86WJ1 | 1/20 | 0.41 |
| ▸ | PARP9 | Q8IXQ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28607646 | 1.00 | KDM4E (0.60) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21597712 | 0.91 | KDM4E (0.47) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21597616 | 0.91 | KDM4E (0.47) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21603737 | 0.90 | KMT2A (0.52) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21597604 | 0.88 | MAPT (0.47) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21603936 | 0.87 | MAPT (0.46) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21603928 | 0.84 | CNR2 (0.46) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21603941 | 0.84 | CNR2 (0.46) | KDM4EHSD17B10MAPTALDH1A1GAA | |
| SCHEMBL21603967 | 0.84 | CNR2 (0.50) | KDM4EHSD17B10MAPTALDH1A1FLT3 | |
| SCHEMBL28609323 | 0.84 | CNR2 (0.46) | KDM4EHSD17B10MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |