Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21597822 | 0.86 | CNR2 (0.57) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL28920828 | 0.85 | CNR2 (0.50) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21597817 | 0.85 | CNR2 (0.50) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21597261 | 0.85 | CNR2 (0.50) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21597867 | 0.85 | CNR2 (0.46) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21597580 | 0.85 | CNR2 (0.46) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21603872 | 0.81 | CNR2 (0.45) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL28618673 | 0.80 | KDM4E (0.70) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21603914 | 0.80 | KDM4E (0.70) | CNR2CNR1FLT3KDM4EHSD17B10 | |
| SCHEMBL21597849 | 0.79 | FLT3 (0.40) | CNR2CNR1FLT3KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |