Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22449310 | 0.98 | CHRM1 (0.34) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL20942447 | 0.88 | CHRM1 (0.42) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL17101289 | 0.88 | CHRM1 (0.42) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL29859951 | 0.88 | CHRM1 (0.42) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL20942069 | 0.88 | CHRM1 (0.42) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL22449304 | 0.87 | CYP11B1 (0.33) | CYP11B1CYP11B2 | |
| SCHEMBL22449320 | 0.87 | CHRM1 (0.40) | CHRM1CHRM4CHRM5CHRM2MAPK1 | |
| SCHEMBL17101370 | 0.86 | CHRM1 (0.40) | CHRM1CHRM4CHRM5CHRM2CHRM3 | |
| SCHEMBL17101337 | 0.84 | CHRM1 (0.43) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 | |
| SCHEMBL22472870 | 0.84 | CYP11B1 (0.35) | CHRM1CYP11B1CYP11B2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810614-A1 | BRIDGED COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 AND/OR M4 RECEPTOR | Heptares Therapeutics Limited (GB) | 2021-04-28 | — | — | EP | claimed |
| WO-2019243851-A1 | BRIDGED COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 AND/OR M4 RECEPTOR | HEPTARES THERAPEUTICS LIMITED (GB) | 2019-12-26 | — | — | WO | claimed |