Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | WEE1 | P30291 | 2/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21600766 | 0.93 | FGFR1 (0.54) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600807 | 0.92 | JAK3 (0.54) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600927 | 0.91 | JAK3 (0.53) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600915 | 0.91 | JAK3 (0.49) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600921 | 0.90 | LRRK2 (0.52) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600920 | 0.89 | JAK3 (0.51) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600813 | 0.89 | FGFR1 (0.51) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL25139904 | 0.89 | JAK3 (0.52) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL30043973 | 0.89 | JAK3 (0.52) | JAK3FGFR1WEE1BTKALK | |
| SCHEMBL21600786 | 0.88 | MAPK3 (0.52) | JAK3FGFR1WEE1BTKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |