Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.58 |
| ▸ | KDM1A | O60341 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | GPR4 | P46093 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21604566 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL20281548 | 1.00 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21604516 | 0.91 | MAP2K1 (0.51) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL20281495 | 0.91 | MAP2K1 (0.51) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21604534 | 0.91 | MAP2K1 (0.51) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21607279 | 0.90 | SLC6A2 (0.56) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21603166 | 0.89 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21604593 | 0.81 | MAP2K1 (0.46) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL21604589 | 0.81 | MAP2K1 (0.46) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 | |
| SCHEMBL23481099 | 0.79 | PDE4A (0.38) | SLC6A2SLC6A4SLC6A3KDM1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277015-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN-CILAG S.A. (ES) | 2021-09-09 | — | — | US | disclosed |
| US-20210115040-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-22 | — | — | US | disclosed |
| WO-2019243528-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243527-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277015-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | SLC6A2 3601/4885SLC6A4 3676/4885SLC6A3 3377/4885 |
| US-20210115040-A1 | OGA INHIBITOR COMPOUNDS | OGA, OGT, GRN | SLC6A2 3601/4885SLC6A4 3676/4885SLC6A3 3377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.