Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 5/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.70 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.68 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.68 |
| ▸ | CCR3 | P51677 | 14/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21604548 | 1.00 | OGA (0.70) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL28564168 | 0.89 | OGA (0.70) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL21369614 | 0.89 | OGA (0.70) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL21604651 | 0.89 | OGA (0.70) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL21370299 | 0.83 | OGA (0.61) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL28574849 | 0.83 | OGA (0.61) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL28573623 | 0.83 | OGA (0.61) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| SCHEMBL21369468 | 0.83 | OGA (0.61) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| Jnj-65355394 SCHEMBL20281725 | 0.82 | OGA (1.00) | OGAOPRK1SLC6A4SLC6A3ADRA2B | |
| Jnj-65355394 SCHEMBL20281723 | 0.82 | OGA (1.00) | OGAOPRK1SLC6A4SLC6A3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243528-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243530-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243526-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |