Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 4/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21604661 | 1.00 | EED (0.44) | EEDHRH4HRH3KCNH2CHEK1 | |
| SCHEMBL21603171 | 0.92 | HRH4 (0.40) | EEDHRH4HRH3CHEK1HSP90AA1 | |
| SCHEMBL20281715 | 0.92 | HRH4 (0.40) | EEDHRH4HRH3CHEK1HSP90AA1 | |
| SCHEMBL21359121 | 0.86 | EED (0.52) | EEDHRH4HRH3KCNH2BRD4 | |
| SCHEMBL20281478 | 0.86 | EED (0.52) | EEDHRH4HRH3KCNH2BRD4 | |
| SCHEMBL21604662 | 0.81 | EED (0.44) | EEDHRH4HRH3KCNH2CHEK1 | |
| SCHEMBL21604667 | 0.81 | EED (0.44) | EEDHRH4HRH3KCNH2CHEK1 | |
| SCHEMBL21605727 | 0.79 | BRD4 (0.43) | KCNH2CHEK1BRD4ATAD2 | |
| SCHEMBL21604575 | 0.78 | EED (0.54) | EEDHRH4HRH3KCNH2BRD4 | |
| SCHEMBL21604573 | 0.78 | EED (0.54) | EEDHRH4HRH3KCNH2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243528-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |
| WO-2019243526-A1 | OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2019-12-26 | — | — | WO | disclosed |