Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | BPTF | Q12830 | 2/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21605468 | 1.00 | MAPT (0.44) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL21605400 | 1.00 | MAPT (0.44) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL21598798 | 0.81 | GAA (0.48) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL21605362 | 0.79 | ADORA1 (0.39) | MAPTKDM4EADORA1SCN4ANR1H2 | |
| SCHEMBL29839803 | 0.77 | ADORA1 (0.61) | MAPTGAAKDM4EADORA1ALDH1A1 | |
| SCHEMBL27077173 | 0.77 | ADORA1 (0.61) | MAPTGAAKDM4EADORA1ALDH1A1 | |
| SCHEMBL21598805 | 0.76 | MAPT (0.45) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL32682825 | 0.76 | GAA (0.47) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL31729875 | 0.76 | GAA (0.47) | MAPTGAAKDM4EBPTFADORA1 | |
| SCHEMBL32682826 | 0.76 | GAA (0.47) | MAPTGAAKDM4EBPTFADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810613-B1 | N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2023-01-11 | — | — | EP | disclosed |
| WO-2019244047-A1 | N-SUBSTITUTED TETRAHYDROTHIENOPYRIDINE DERIVATIVES AND USES THEREOF | NOVARTIS AG (CH) | 2019-12-26 | — | — | WO | disclosed |