Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 20/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788857 | 0.87 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15775012 | 0.86 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15788869 | 0.86 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15774762 | 0.85 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15774492 | 0.84 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15774999 | 0.83 | CNR2 (1.00) | CNR2 | |
| SCHEMBL21609545 | 0.83 | CNR2 (0.82) | CNR2 | |
| SCHEMBL15788861 | 0.82 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15788903 | 0.82 | CNR2 (1.00) | CNR2 | |
| SCHEMBL14901918 | 0.81 | CNR2 (1.00) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814328-B1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | HOFFMANN LA ROCHE (CH) | 2026-03-11 | — | — | EP | disclosed |
| US-12180196-B2 | Azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 | HOFFMANN-LA ROCHE INC. (US) | 2024-12-31 | — | — | US | disclosed |
| US-20210130334-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | HOFFMANN-LA ROCHE INC. (US) | 2021-05-06 | — | — | US | disclosed |
| US-20210130334-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | HOFFMANN-LA ROCHE INC. (US) | 2021-05-06 | — | — | US | disclosed |
| EP-3814328-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | F. Hoffmann-La Roche AG (CH) | 2021-05-05 | — | — | EP | disclosed |
| CN-112119068-A | Novel azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 | 豪夫迈·罗氏有限公司 | 2020-12-22 | — | — | CN | disclosed |
| WO-2020002280-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-02 | — | — | WO | disclosed |
| WO-2020002280-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | F. HOFFMANN-LA ROCHE AG (CH) | 2020-01-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12180196-B2 | Azetidine-substituted pyridine and pyrazine compounds as inhibitors of cannabinoid receptor 2 | CNR1, CNR2, NPY1R | CNR2 2/4885 |
| US-20210130334-A1 | NOVEL AZETIDINE-SUBSTITUTED PYRIDINE AND PYRAZINE COMPOUNDS AS INHIBITORS OF CANNABINOID RECEPTOR 2 | CNR1, CNR2, NPY1R | CNR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.