Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 3/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21614771 | 0.82 | CYP2C19 (0.58) | IDH1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21612023 | 0.80 | IDH1 (0.46) | IDH1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21614661 | 0.79 | CYP2C19 (0.57) | VNN1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21614656 | 0.78 | CYP2C19 (0.52) | VNN1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21614646 | 0.72 | CYP2C19 (0.70) | VNN1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL21611949 | 0.70 | CYP2C19 (0.55) | VNN1IDH1CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL21611972 | 0.65 | CYP2C19 (0.46) | IDH1CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL29277919 | 0.65 | NPC1 (0.39) | CYP1A2HDAC6IDO1 | |
| SCHEMBL29939945 | 0.65 | NPC1 (0.39) | CYP1A2HDAC6IDO1 | |
| SCHEMBL25124381 | 0.65 | SMARCA2 (0.48) | IDH1CYP2C19CYP2C9CYP3A4LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-11-18 | — | — | US | disclosed |
| EP-3818045-A1 | PQSR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2021-05-12 | — | — | EP | disclosed |
| WO-2020007938-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-01-09 | — | — | WO | disclosed |
| WO-2020007938-A1 | PqsR INVERSE AGONISTS | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2020-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353606-A1 | PqsR INVERSE AGONISTS | QRFPR, P2RY11, QARS1 | VNN1 4567/4885IDH1 3267/4885CYP2C19 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.