Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.34 |
| ▸ | CTSA | P10619 | 4/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613536 | 0.90 | ABL1 (0.35) | GRIN2BTGFBR1CTSAGPBAR1MAPT | |
| SCHEMBL21613452 | 0.84 | GRIN2B (0.40) | GRIN2BGSK3ACASP3SENP8SENP7 | |
| SCHEMBL17408894 | 0.84 | GRIN2B (0.40) | GRIN2BPIM1SRCGSK3ANISCH | |
| SCHEMBL21613511 | 0.83 | GRIN2B (0.39) | GRIN2BGRIN1 | |
| SCHEMBL21613575 | 0.82 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL21613516 | 0.81 | CLK1 (0.36) | GRIN2BCTSAKDM1AHDAC1HDAC6 | |
| SCHEMBL21613471 | 0.81 | GRIN2B (0.43) | GRIN2BGRIN1 | |
| SCHEMBL21613450 | 0.79 | PDGFRB (0.43) | GRIN2BGRIN1 | |
| SCHEMBL21613479 | 0.79 | GRIN2B (0.39) | GRIN2BGRIN1 | |
| SCHEMBL21613482 | 0.79 | PDGFRB (0.40) | HDAC1MAPTSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |