Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 13/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21613535 | 0.91 | GRIN2B (0.41) | GRIN2BGRIN1CDK8 | |
| SCHEMBL21613471 | 0.85 | GRIN2B (0.43) | GRIN2BGRIN1KCNH2 | |
| SCHEMBL21613450 | 0.84 | PDGFRB (0.43) | GRIN2BGRIN1 | |
| SCHEMBL21613454 | 0.79 | GRIN2B (0.42) | GRIN2BGRIN1CDK8 | |
| SCHEMBL21613456 | 0.78 | PDGFRB (0.40) | GRIN2BGRIN1 | |
| SCHEMBL21613484 | 0.75 | PDGFRB (0.43) | GRIN2BGRIN1 | |
| SCHEMBL21613468 | 0.75 | VRK1 (0.38) | GRIN2BGRIN1 | |
| SCHEMBL21613482 | 0.74 | PDGFRB (0.40) | — | |
| SCHEMBL21613536 | 0.74 | ABL1 (0.35) | GRIN2B | |
| SCHEMBL21613591 | 0.73 | GRIN2B (0.35) | GRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319963-B1 | SUBSTITUTED 4-AZAINDOLES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-01-08 | — | — | EP | disclosed |